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Daily recombinant growth hormone GH injections are indicated for children with PWS. GH supports linear growth and increased muscle mass, and may lessen food preoccupation and weight gain.
Methylation-specific testing is important to confirm the diagnosis of PWS in all individuals, but especially those who are too young to manifest sufficient features to make the diagnosis on clinical grounds or in those individuals who have atypical findings.
PWS is often misdiagnosed as other syndromes due to many in the medical community's unfamiliarity with it. PWS has no cure; several treatments are available to lessen the condition's symptoms.
During infancy, subjects should undergo therapies to improve muscle strength. Speech and occupational therapy are also indicated. During the school years, children benefit from a highly structured learning environment and extra help.
The largest problem associated with the syndrome is severe obesity. Access to food must be strictly supervised and limited, usually by installing locks on all food-storage places including refrigerators.
Prescription of daily recombinant GH injections are indicated for children with PWS. Because of severe obesity, obstructive sleep apnea is a common sequela , and a positive airway pressure machine is often needed.
A person who has been diagnosed with PWS may have to undergo surgical procedures. One surgery that has proven to be unsuccessful for treating the obesity is gastric bypass.
Behavior and psychiatric problems should be detected early for the best results. These issues are best when treated with parental education and training.
Sometimes medication is introduced, as well. Serotonin agonists have been most effective in lessening temper tantrums and improving compulsivity.
PWS affects one in 10, to one in 25, newborns. Despite its rarity, PWS has been often referenced in popular culture, partly due to curiosity surrounding the insatiable appetite and fascination with the trademark obesity symptomatic of the Syndrome.
The syndrome has been depicted and documented several times in television. A fictional individual with PWS featured in the episode "Dog Eat Dog" of the television series CSI: Crime Scene Investigation , which aired in the US on 24 November From Wikipedia, the free encyclopedia.
Rare genetic disorder caused by part of the father's chromosome 15 being missing. Reduced fetal movement Frequent abnormal fetal position Occasional polyhydramnios excessive amniotic fluid Often breech or caesarean births Lethargy Hypotonia Feeding difficulties due to poor muscle tone affecting sucking reflex Difficulties establishing respiration Hypogonadism.
Excessive weight gain Sleep disorders Delayed puberty Short stature Obesity Extreme flexibility. Prominent nasal bridge Small hands and feet with tapering of fingers Soft skin, which is easily bruised Excess fat, especially in the central portion of the body High, narrow forehead Thin upper lip Downturned mouth Almond-shaped eyes Light skin and hair relative to other family members Lack of complete sexual development Frequent skin picking Stretch marks Delayed motor development.
Archived from the original on August 21, Retrieved August 20, Genetics Home Reference. June Archived from the original on August 27, Retrieved August 19, January 14, In a Page: Pediatrics.
Archived from the original on August 10, Archived from the original on July 27, Genetic Home Reference. May Classical and Molecular Genetics. American Academic Press.
Archived from the original on September 11, Elsevier Health Sciences.
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